What is PNC-27?
PNC-27 (HDM2-targeting chimeric anticancer peptide) is a 32-amino acid chimeric peptide (HDM2-binding + penetratin). Chimeric peptide combining an HDM2 (human double minute 2)-binding domain with a penetratin cell-penetrating sequence. Proposed mechanism: binds membrane-associated HDM2 overexpressed on cancer cell surfaces, disrupting p53-HDM2 interaction and inducing selective cancer cell membranolysis while sparing normal cells.
Research Applications
HDM2-p53 Disruption
Protein interaction inhibition at MDM2/HDM2-p53 interface
Cancer-Selective Lysis
Membrane-targeted anticancer peptide mechanism research
Cell Penetrating Delivery
Penetratin-mediated intracellular delivery system biology
Cancer vs Normal Cells
Selectivity mechanism — HDM2 overexpression in cancer
vs Small Molecule MDM2i
Comparison with nutlin-3, AMG-232 mechanism and selectivity
Quick Specs
| Form |
Sequence-dependent (33-amino-acid peptide) |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
Not publicly standardized |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Anti-Aging & Longevity |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
