What is MOTS-c?
MOTS-c (Mitochondria-derived peptide (mitochondrial 12S rRNA-encoded)) is a 16-amino acid mitochondria-encoded peptide. Mitochondria-derived peptide encoded by the 12S rRNA gene — translocates to the nucleus under metabolic stress to regulate AMPK and folate-methionine cycle activity. Declines with age. Extends lifespan in aged male mice, improves insulin sensitivity, exercise capacity, and thermogenic response to cold stress.
Research Applications
Retrograde Signalling
Mitochondria-to-nucleus communication under metabolic stress
AMPK Activation
Energy sensor activation, cellular fuel switch, autophagy
Insulin Sensitivity
Glucose uptake, GLUT4 translocation, insulin resistance models
Exercise & Metabolism
VO2 max, muscle metabolism, endurance capacity research
Longevity Biology
Age-related decline, mitokine signalling, lifespan extension
Quick Specs
| Form |
Sequence-specific (16-amino-acid mitochondrial-der |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
Not publicly standardized |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Asia |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized MOTS-c vial. Swirl gently until dissolved. MOTS-c is a 16-amino acid peptide that dissolves readily to a clear, colourless solution.
How should this peptide be stored?
Store lyophilized at −20°C. Reconstituted: 2–8°C for up to 28 days. Avoid repeated freeze-thaw cycles and protect from UV light.
What purity is this QSC compound and how is it verified?
QSC MOTS-c is ≥99% HPLC pure with MS-confirmed 16-amino acid sequence on every batch. COA is published on the product page and verifiable at verify.janoshik.com.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
