What is Orforglipron?
Orforglipron (Oral non-peptide allosteric GLP-1R agonist) is a Small molecule (MW ~450, non-peptide). First non-peptide GLP-1R agonist approved (2025). Activates GLP-1R via allosteric (not orthosteric) binding — enabling oral bioavailability without peptide backbone. Biased agonism profile differs from peptide GLP-1R agonists. ATTAIN Phase 3: ~14.7% weight reduction at 36 weeks.
Research Applications
Allosteric GLP-1R Agonism
Allosteric vs orthosteric receptor binding comparison research
Oral Bioavailability
No injection stress confound — oral GLP-1R biology in rodent models
Biased Signalling
Small molecule vs peptide GLP-1R agonist downstream bias
Obesity Research
ATTAIN Phase 3 reference — 14.7% weight reduction at 36 weeks
vs Injectable GLP-1R
Mechanism and downstream signalling comparison
Quick Specs
| Form |
Lyophilized powder |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
2211316-73-5 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months sealed |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
QSC research tablets are supplied as pre-dosed oral tablets at the stated concentration. No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications.
How should this peptide be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight. Keep in the original container. Properly stored tablets remain stable for 2–3 years.
What purity is this QSC compound and how is it verified?
QSC research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
