What is KPV?
KPV (Alpha-MSH(11-13) — Anti-inflammatory tripeptide (Lys-Pro-Val)) is a 3-amino acid C-terminal alpha-MSH fragment. C-terminal tripeptide of alpha-MSH (Lys-Pro-Val) retaining anti-inflammatory activity via MC1R modulation. Inhibits NF-κB nuclear translocation, reduces IL-6, IL-8, and TNF-α production, and shows particular efficacy in intestinal epithelial and GI inflammation models.
Research Applications
NF-κB Inhibition
Nuclear translocation block — downstream cytokine reduction
MC1R Modulation
Melanocortin-1 receptor anti-inflammatory pathway
GI Inflammation
Intestinal epithelial protection, IBD models, mucosal healing
vs Full Alpha-MSH
Minimal active fragment — residues 11-13 vs full 13aa peptide
Cytokine Reduction
IL-6, IL-8, TNF-α reduction — inflammatory biology research
Quick Specs
| Form |
C₁₆H₃₀N₄O₅ |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
67727-97-3 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Asia |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
