What is Tesofensine?
Tesofensine is a triple monoamine reuptake inhibitor — simultaneously blocking DAT, SERT, and NET. Originally developed for Parkinson’s and Alzheimer’s, it demonstrated exceptional appetite suppression and weight loss in Phase 2 obesity trials. Phase 2 (2008): 10.6% body weight reduction at 0.5mg/day over 24 weeks. CAS 195875-84-4.
Research Applications
Triple Reuptake Inhibition
DAT/SERT/NET — hypothalamic appetite circuit modulation
Obesity Pharmacology
Phase 2: 10.6% weight reduction — comparison vs GLP-1R class
Monoamine Neuroscience
DA/5HT/NE selectivity and occupancy studies
Energy Expenditure
Sympathomimetic thermogenesis — BAT activation
Addiction Research
Dopamine reuptake inhibition — reward pathway pharmacology
Quick Specs
| Form | C₁₇H₂₃ClN₂O |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 195875-84-4 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months unopened |
| Storage | Room temperature sealed | cool, dry storage |
| Manufacture | In-house synthesis — Qingdao, China |
| Brand | China |
Certificate of Analysis (COA)
Frequently Asked Questions
🧪 Peptide Research Tools: Use QSC's free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
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🌏 International shipping: 7–14 days