What is Sildenafil?
Sildenafil (Viagra/Revatio) is the first-in-class PDE5 inhibitor — selective for PDE5 over PDE6 (10×) and PDE1 (80×). Half-life ~4hr — suitable for acute response and dose-response studies. FDA-approved for erectile dysfunction and PAH (Revatio). Reference compound for NO/cGMP pathway research. CAS 139755-83-2.
Research Applications
NO/cGMP Reference Compound
First-in-class PDE5 inhibitor — foundational cGMP signalling
Acute PDE5 Inhibition
4hr half-life — acute onset/offset and dose-response kinetics
Pulmonary Hypertension
Revatio indication — pulmonary vascular resistance research
PDE Selectivity Profile
PDE5 vs PDE6 vs PDE1 selectivity — comparative PDE pharmacology
vs Tadalafil Comparison
Short-acting vs long-acting PDE5 — duration studies
Quick Specs
| Form | C₂₂H₃₀N₆O₄S |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 139755-83-2 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months unopened |
| Storage | Room temperature sealed | cool, dry storage |
| Manufacture | In-house synthesis — Qingdao, China |
| Brand | China |
Frequently Asked Questions
🧪 Peptide Research Tools: Use QSC's free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
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