What is GW501516 Cardarine?
GW501516 (Cardarine) is a selective PPARδ agonist — not a SARM (no AR activity). Activates PPARδ → GLUT4, fatty acid oxidation genes (CPT1, HADHA), and mitochondrial biogenesis in skeletal muscle. Dramatically increases running endurance in mice without training. CAS 317318-70-0.
Research Applications
PPARδ Agonism
Nuclear receptor activation — fatty acid oxidation gene programme
Exercise Mimicry
Endurance enhancement without training — AMPK-independent
Fatty Acid Oxidation
CPT1/HADHA/PDHK4 upregulation — skeletal muscle lipid utilisation
Mitochondrial Biogenesis
PPARδ → PGC-1α co-activation — mitochondrial content increase
vs AICAR/MOTS-c Comparison
PPARδ vs AMPK exercise mimicry — mechanistic dissection
Quick Specs
| Form | C₂₁H₁₈F₃NO₃S₂ |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 317318-70-0 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months unopened |
| Storage | Room temperature sealed | cool, dry storage |
| Manufacture | In-house synthesis — Qingdao, China |
| Brand | China |
Certificate of Analysis (COA)
Frequently Asked Questions
🧪 Peptide Research Tools: Use QSC's free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
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