What is Sildenafil?
Sildenafil Citrate is a potent, selective PDE5 (phosphodiesterase type 5) inhibitor. Blocks cGMP degradation, elevating intracellular cGMP and mediating smooth muscle relaxation via PKG activation. Standard PDE5 inhibitor reference compound for vascular biology, erectile physiology, pulmonary hypertension, and cGMP pathway research. Research use only.
Research Applications
PDE5 Inhibition Pharmacology
IC50, selectivity panel (PDE1–11), cGMP elevation kinetics — reference compound
Erectile Physiology Research
Corpus cavernosum smooth muscle relaxation, haemodynamic models, NO-cGMP amplification
Pulmonary Hypertension
Pulmonary vascular resistance, PDE5 expression in lung, vasorelaxation studies
Endothelial Function
NO pathway amplification, endothelial cGMP signalling, vascular tone modulation
PDE6 Cross-Reactivity
Sildenafil PDE6 inhibition — visual side effect mechanism, retinal photoreceptor research
Quick Specs
| Form |
C28H38N6O11S, MW 666.7 |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
171599-83-0 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months (unopened) |
| Storage |
Room temperature sealed | cool, dry storage |
| Manufacture |
In-house synthesis — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
QSC raw powder compounds are supplied as bulk crystalline or amorphous powder in a sealed, labelled container at the stated quantity. No reconstitution is required — the powder is ready for weighing and use in research applications.
How should this peptide be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct light. Keep in the original sealed container. Properly stored raw powder remains stable for 2–3 years.
What purity is this QSC compound and how is it verified?
All QSC raw powder compounds are tested to ≥99% purity by HPLC on every production batch, with MS-confirmed identity. COA is published on the product page and independently verifiable at verify.janoshik.com.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
Room temperature sealed | cool, dry storage
