What is PE-22-28?
PE-22-28 (Spadin analog — TREK-1 potassium channel blocker) is a 7-amino acid synthetic spadin-derived peptide. Synthetic spadin-derived peptide blocking the TREK-1 (TRAAK-related potassium channel-1) two-pore-domain K⁺ channel, which is overexpressed in depression models and reduces neuronal excitability. TREK-1 blockade increases firing rate and serotonin release — antidepressant mechanism without SSRI profile or sedation.
Research Applications
TREK-1 Channel Pharmacology
Two-pore-domain K⁺ channel block — neuronal excitability increase
Antidepressant Biology
Depression model research without SSRI target or sedation
Sortilin/Spadin Axis
Sortilin propeptide biology, TREK-1 regulation mechanism
Serotonin Release
5-HT release augmentation via neuronal depolarisation
Ion Channel Research
K⁺ channel pharmacology, membrane potential, firing rate studies
Quick Specs
| Form |
Sequence-dependent (7-amino-acid peptide) |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
Not publicly standardized |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Asia |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
