What is Dermorphin??
Dermorphin (CAS 77614-16-5) is a naturally occurring heptapeptide opioid first isolated from the skin of South American frogs (Phyllomedusa sauvagei). Sequence: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂. Molecular formula C₄₀H₅₀N₈O₁₀, MW 802.88 g/mol. Notably, it contains a D-alanine residue at position 2 — rare in vertebrate peptides — which confers resistance to enzymatic degradation. Dermorphin has approximately 1,000-fold greater potency at µ-opioid receptors (MOR) than morphine in preclinical binding assays, with high selectivity for MOR over δ and κ receptors. It is a fundamental research tool for opioid receptor pharmacology.
Research Applications
µ-Opioid Receptor Pharmacology
MOR binding affinity, Gi/o signalling, receptor selectivity vs. DOR/KOR profiling
Opioid Analgesia Research
Central and peripheral analgesic mechanisms, tolerance and sensitisation models
D-Amino Acid Stability
Enzymatic resistance studies — D-Ala² contribution to DPP-IV and protease stability
Receptor Signalling
cAMP suppression, GIRK channel activation, β-arrestin bias studies
Comparative Opioid Studies
Potency ratio comparisons with morphine, DAMGO, and endomorphins
Quick Specs
| Form |
C₄₀H₅₀N₈O₁₀ |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
77614-16-5 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
