What is ACE-031??
ACE-031 (also known as Ramatercept, CAS 1621169-52-5) is a recombinant fusion protein composed of the extracellular ligand-binding domain of activin receptor type IIB (ACVR2B) linked to the Fc region of human IgG1. It functions as a soluble decoy receptor, sequestering myostatin (GDF-8), activin A, activin B, GDF-11, and BMP-9 in circulation — preventing these negative regulators from binding membrane-bound ACVR2B on muscle and bone cells. Developed by Acceleron Pharma, ACE-031 has a half-life of approximately 10–15 days in human pharmacokinetic studies.
Research Applications
Myostatin / ACVR2B Signalling
Myostatin-SMAD2/3 pathway suppression, receptor downregulation, ligand-trap kinetics
Skeletal Muscle Biology
Fiber cross-sectional area hypertrophy, anabolic protein synthesis, DMD & ALS wasting models
Bone Metabolism
Biomarker shifts in bone formation vs. resorption, lumbar spine mineral density studies
Fat Metabolism
Adipose lipolysis changes associated with ActRIIB ligand inhibition
Pharmacokinetics
AUC(0-∞), Cmax linear dose-response, T½ 10–15 day profiling
Quick Specs
| Form |
C₃₄₁₈H₅₁₈₈N₉₂₈O₁₀₆₂S₃₈ |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
1621169-52-5 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Asia |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
