What is Gonadorelin??
Gonadorelin (CAS 33515-09-2) is the synthetic form of endogenous gonadotropin-releasing hormone (GnRH / LHRH) — a 10-amino acid hypothalamic decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂). Molecular formula C₅₅H₇₅N₁₇O₁₃, MW 1182.31 g/mol. Released in pulses from hypothalamic GnRH neurons, it binds the GnRHR (Gq/PLC/IP₃) on anterior pituitary gonadotrophs — stimulating LH and FSH synthesis and secretion. Pulsatile gonadorelin activates the HPG axis; continuous administration causes receptor downregulation and gonadotropin suppression — making it the definitive tool for studying pulse-dependent HPG axis regulation.
Research Applications
HPG Axis Pulsatility
Pulsatile vs. continuous GnRHR stimulation, LH/FSH pulse amplitude and frequency regulation
GnRH Receptor Pharmacology
GnRHR binding kinetics, Gq/PLC/IP₃ signalling, receptor internalisation, desensitisation
Gonadotropin Secretion
LH and FSH release from anterior pituitary gonadotrophs, surge vs. tonic secretion modelling
Male Reproductive Research
Testosterone axis (GnRH→LH→Leydig→T), spermatogenesis, hypogonadotropic hypogonadism models
Female Reproductive Biology
Folliculogenesis, ovulation induction, estradiol/progesterone cycling, PCOS models
Quick Specs
| Form | C₅₅H₇₅N₁₇O₁₃ |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 33515-09-2 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months unopened |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Brand | Asia |