What is Cortagen??
Cortagen (Ala-Glu-Asp-Pro, AEDP, molecular formula C17H27N5O8, MW 430.17 g/mol) is a synthetic tetrapeptide bioregulator from the Khavinson Cytogen family, developed at the St. Petersburg Institute of Bioregulation and Gerontology. It primarily targets cerebral cortex tissue through tissue-specific DNA promoter binding and nuclear gene expression modulation. Research in neural models demonstrates that Cortagen hyperpolarises neurons, reduces spontaneous firing, and exhibits neuroprotective and nerve-regenerative properties. Microarray studies in mouse heart tissue also identified significant gene expression changes – indicating secondary cardiovascular activity. Cortagen is distinct from Epithalon (a related tetrapeptide) in its amino acid composition and resulting tissue targeting specificity.
Research Applications
CNS Neuroprotection
Neuronal hyperpolarisation, reduced spontaneous activity, ischaemic brain injury attenuation – neuronoprotective action profiling
Peripheral Nerve Regeneration
Injured nerve function restoration after transection, electrophysiological parameters, sciatic nerve recovery models
Brain Cortex Gene Expression
Microarray profiling of cortagen-induced gene changes in cortical tissue, DNA promoter binding specificity
Inflammatory Balance
CNS inflammatory pathway modulation, pro/anti-inflammatory cytokine equilibrium in neural tissue models
Anti-Ageing & Geroprotection
DNA repair toward youthful state, senescence reduction, age-related cortical decline reversal in geriatric models
Quick Specs
| Form | C17H27N5O8 |
| Purity | >=99% by HPLC – every batch |
| Molecular Weight | MS molecular weight confirmed – every batch |
| Specification | >=99% by HPLC – every batch |
| Shelf Life | 24 months unopened |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Brand | Anti-Aging & Longevity |