What is Orexin B (High-Dose)??
Orexin B (Hypocretin-2, CAS 205640-91-1) is a 28-amino acid OX2R-selective hypothalamic neuropeptide. This 10mg/vial high-dose format supports research protocols requiring larger quantities – dose-escalation OX2R receptor occupancy studies, multi-cohort sleep paradigms, high-throughput competitive binding assays, or extended in vivo infusion experiments investigating OX2R-mediated histaminergic arousal, sleep-wake architecture, or suvorexant mechanism-of-action comparisons. The 10mg format also enables combination assays comparing Orexin B (OX2R-selective) vs. Orexin A (OX1R/OX2R dual) biology side-by-side with adequate quantities for both arms.
Research Applications
High-Dose OX2R Occupancy
Dose-escalation receptor saturation kinetics, Bmax/Kd determination in hypothalamic membrane preparations
Multi-Cohort Sleep Studies
Sufficient for large-animal or multi-arm sleep EEG studies requiring repeated orexin B administration
High-Throughput Receptor Screening
Competitive binding assays – Orexin B as OX2R radioligand competitor against novel antagonist libraries
Suvorexant Mechanism Studies
OX2R occupancy correlation with sleep onset/maintenance – comparison with dual OX1R/OX2R blockade
Comparative Orexin Biology
Orexin A vs. B functional comparison assay – OX1R-specific phenotypes vs. OX2R-specific phenotypes with 10mg of each
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 205640-91-1 |
| Molecular Weight | MS molecular weight confirmed – every batch |
| Specification | >=99% by HPLC – every batch |
| Shelf Life | 24 months unopened |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Brand | Asia |