What is Crystagen??
Crystagen (peptide complex AC-5/AC-6, amino acids Pro-Glu-Asp) is a synthetic short-peptide bioregulator from the Khavinson Cytogen family, developed at the St. Petersburg Institute of Bioregulation and Gerontology for immune system restoration. It exhibits selective action on thymus tissue – improving thymic metabolism and tissue regeneration to restore T-cell synthesis, maturation and release. Unlike Vladonix (natural thymus extract), Crystagen as a Cytogen acts faster but with shorter duration. Research demonstrates Crystagen activates B-cell immune pathways in the spleen, increases CD3+/CD4+ T-cell counts, normalises CD4+/CD8+ ratios, preserves thymic cortex-medulla architecture, stimulates thymocyte proliferation (PCNA expression), and exhibits immunogeroprotective effects in gamma-irradiation accelerated ageing models.
Research Applications
Thymic Tissue Regeneration
Thymic metabolism restoration, cortex-medulla architecture preservation, T-cell maturation and release enhancement
T-Cell Immunology
CD3+/CD4+ T-cell count normalisation, CD4+/CD8+ ratio restoration, T-helper cell activation, PCNA proliferation marker
B-Cell & Splenic Immunity
B-lymphocyte activation in spleen, immunomodulatory effects distinct from T-cell bioregulators (vilon, thymogen)
Immunogeroprotection
Gamma-irradiation accelerated ageing model – thymic preservation, macrophage/mast cell restoration, age-related immune decline reversal
Immunodeficiency Restoration
Secondary immunodeficiency models (radiation, chemotherapy, infection) – immunogram normalisation, asthenic syndrome reduction
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| Molecular Weight | MS molecular weight confirmed – every batch |
| Specification | >=99% by HPLC – every batch |
| Shelf Life | 24 months unopened |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Brand | Anti-Aging & Longevity |