What is Dihexa (High-Dose)??
Dihexa (PNB-0408, CAS 1239264-98-2) is a highly CNS-penetrant HGF/MET-potentiating peptidomimetic that drives de novo synaptogenesis — estimated at 10⁷-fold greater potency than BDNF for new dendritic spine formation. This 10mg/vial high-dose format supports dose-escalation protocols, multi-cohort neurodegeneration studies, transdermal delivery experiments, and long-duration cognitive paradigms where larger quantities per session are required. Molecular formula C₂₄H₃₉N₃O₄, MW 437.58 g/mol.
Research Applications
High-Dose Synaptogenesis
Dose-escalation dendritic spine density, concentration-response at HGF/MET receptor
Extended Cognitive Studies
Multi-week spatial learning, fear conditioning, and NOR paradigms requiring higher peptide reserves
Transdermal Delivery Research
Lipophilicity-driven skin penetration studies, bioavailability comparison vs. sc/ip routes
Neurodegeneration Reversal
High-dose Alzheimer’s-model synapse recovery, AChE-lesion and Aβ model synaptogenesis restoration
Neuroplasticity Mechanisms
LTP, AMPA/NMDA receptor trafficking, PSD-95 clustering under sustained HGF/MET activation
Quick Specs
| Form |
C₂₄H₃₉N₃O₄ |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
1239264-98-2 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Anti-Aging & Longevity |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
