What is Mazdutide 5mg?
Mazdutide (IBI362) is a weekly dual GLP-1R/GCGR (glucagon receptor) agonist developed by Innovent Biologics. The GLP-1R component provides appetite suppression and insulin secretion; the GCGR component adds direct hepatic fat mobilisation, thermogenesis via brown adipose tissue activation, and energy expenditure enhancement. Phase 3 GLORY trials in Chinese populations showed superior weight reduction vs semaglutide alone, with additional NAFLD benefit via the glucagon axis. Represents the same mechanistic approach as retatrutide’s GCGR component in a dual (rather than triple) agonist framework.
Research Applications
Dual GLP-1/GCGR Agonism Research
Enables isolation of GCGR contribution to weight loss when combined with GLP-1R agonism — comparison with GLP-1 monotherapy reveals additive glucagon receptor effects on fat mass, hepatic lipid, and energy expenditure.
NASH/NAFLD Research
The GCGR component provides direct hepatic fat mobilisation — mazdutide is studied in NAFLD models where glucagon axis activation reduces liver TG independently of appetite effects.
Comparison vs Semaglutide/Tirzepatide
Phase 3 data positions mazdutide as a distinct dual-agonist comparator. Research comparing GLP-1 mono vs GLP-1+GIP vs GLP-1+GCGR informs next-generation obesity pharmacology.
Quick Specs
| Form |
Lyophilised powder, 10-vial kit |
| Purity |
≥99% HPLC, MS confirmed |
| Specification |
≥99% HPLC, MS confirmed |
| Storage |
−20°C lyophilised; 4°C reconstituted |
| Brand |
Asia |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
−20°C lyophilised; 4°C reconstituted
