What is Melatonin??
Melatonin (N-Acetyl-5-methoxytryptamine, CAS 73-31-4) is an endogenous indole neurohormone synthesised from tryptophan → serotonin → N-acetylserotonin → melatonin in the pineal gland, with peak release in darkness. Molecular formula C₁₃H₁₆N₂O₂, MW 232.28 g/mol. Melatonin acts on MT1 and MT2 G-protein-coupled receptors (Gi-linked, cAMP suppression) to entrain circadian rhythms. It is also a direct free radical scavenger (hydroxyl, peroxynitrite, superoxide), upregulates glutathione peroxidase and superoxide dismutase, and participates in immune modulation and mitochondrial protection at the cellular level.
Research Applications
Circadian Rhythm Research
MT1/MT2 receptor activation, SCN entrainment, phase shifting, jet-lag and shift-work models
Antioxidant Biology
Direct ROS/RNS scavenging, GPx/SOD upregulation, lipid peroxidation inhibition
Sleep Architecture
NREM/REM sleep modulation, sleep onset latency, Zeitgeber synchronisation studies
Oncostatic Research
MT1-mediated oestrogen receptor cross-talk, tumour proliferation inhibition in preclinical models
Mitochondrial Protection
Electron transport chain protection, mitochondrial membrane integrity, cytochrome c release
Quick Specs
| Form |
C₁₃H₁₆N₂O₂ |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
73-31-4 |
| Molecular Weight |
232.28 g/mol |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | protect from light |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Anti-Aging & Longevity |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | protect from light
