What is MGF??
MGF (Mechano Growth Factor) is a splice variant of IGF-1 (the Ec isoform in humans, CAS 87081-35-4) produced locally in muscle tissue in response to mechanical loading or damage. The unique E-domain peptide (24 aa) of MGF activates satellite cell proliferation independently of the IGF-1 receptor — acting through a distinct receptor population to expand the myoblast pool before differentiation. After local depletion (~minutes), circulating systemic IGF-1 drives differentiation and protein synthesis. PEGylated MGF extends this half-life significantly for sustained research models.
Research Applications
Satellite Cell Activation
Muscle stem cell proliferation, E-domain receptor signalling, post-injury myoblast pool expansion
Mechano-Transduction
Mechanical loading → MGF splice induction, IGF-1Ec vs. IGF-1Ea isoform comparison
Muscle Repair Models
Eccentric contraction injury, muscle wasting (cachexia, sarcopenia), re-innervation models
IGF-1 Axis Dissection
MGF vs. systemic IGF-1 temporal sequencing, E-domain vs. IGF-1R activation
Neuroprotection
MGF E-domain peptide neuroprotective effects in motor neuron and cortical neuron models
Quick Specs
| Form |
Lyophilized powder |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
87081-35-4 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
-20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
Asia |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (2–4 weeks)
