What is PEG-MGF??
PEG-MGF (Pegylated Mechano Growth Factor, CAS 88096-37-7) is the polyethylene glycol-conjugated form of native MGF (IGF-1 Ec splice variant). Molecular formula C121H200N42O39, MW ~2888 g/mol (core peptide). PEGylation extends the half-life from ~5-7 minutes (native MGF) to 48-72 hours, enabling systemic distribution and sustained satellite cell activation. PEG-MGF activates muscle stem cells via the IGF-1R/PI3K/Akt/mTOR axis, drives MyoD and myogenin gene expression, and stimulates myofiber regeneration and hypertrophy in preclinical models. Unlike native MGF’s highly localised short-lived paracrine action, PEG-MGF’s sustained circulation enables whole-body satellite cell activation from a single administration.
Research Applications
Satellite Cell Activation
Quiescent satellite cell recruitment, MyoD/myogenin upregulation, myoblast proliferation and fusion
Extended Pharmacokinetics
PEGylation T1/2 48-72h vs. native MGF 5 min – 2-3x/week dosing sufficient for sustained IGF-1R engagement
Muscle Hypertrophy & Repair
PI3K/Akt/mTOR pathway, mTORC1-driven protein synthesis, MRI-confirmed cross-sectional area increase in animal models
Sarcopenia & Wasting Models
Age-related satellite cell decline reversal, cachexia and denervation atrophy models, muscle mass restoration
Systemic vs. Local MGF Comparison
PEG-MGF systemic distribution vs. native MGF localised autocrine/paracrine action – receptor kinetics and tissue distribution
Quick Specs
| Form | C121H200N42O39 |
| Purity | >=99% by HPLC – every batch |
| CAS Number | 88096-37-7 |
| Molecular Weight | MS molecular weight confirmed – every batch |
| Specification | >=99% by HPLC – every batch |
| Shelf Life | 24 months unopened |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Brand | Asia |