What is PNC-27 10mg?
PNC-27 is a 32-amino acid chimeric anticancer peptide containing a p53 HDM-2-binding domain fused to a membrane-destabilising penetratin sequence. It binds HDM-2 (human MDM-2) expressed on the plasma membrane of cancer cells — an expression pattern absent in normal cells — inducing selective membranolysis of tumour cells via a pore-forming mechanism. This selectivity makes PNC-27 a highly specific research tool for studying cancer cell membrane disruption and MDM-2-targeted therapy without affecting normal cell viability.
Research Applications
Selective Tumour Cell Lysis Research
PNC-27 lyses cancer cell lines expressing plasma membrane HDM-2 while sparing normal cells. Standard in vitro readouts: LDH release assay, PI exclusion, MTT viability across cancer vs normal cell panels.
MDM-2/p53 Pathway Research
PNC-27 exploits cancer-specific plasma membrane HDM-2 expression — distinct from nuclear MDM-2 p53 degradation. Research into membranous MDM-2 as a cancer-specific target.
Cancer Cell Line Selectivity Profiling
Mapping HDM-2 plasma membrane expression across cancer cell lines to identify PNC-27-responsive tumour types — pancreatic, breast, and melanoma lines show high sensitivity.
Quick Specs
| Form |
Lyophilised powder, 10-vial kit |
| Purity |
≥99% HPLC, MS confirmed |
| Specification |
≥99% HPLC, MS confirmed |
| Storage |
−20°C lyophilised; 4°C reconstituted |
| Brand |
Anti-Aging & Longevity |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
−20°C lyophilised; 4°C reconstituted
