What is Andarine (S4)?
Andarine (S4) is a nonsteroidal SARM with partial AR agonist activity. Originally developed by GTx as a prostate-targeted androgen. Partial agonist profile produces anabolic activity in muscle and bone with lower full-agonist efficacy than testosterone. Notable for its partial agonism mechanism and visual side effect profile (retina AR binding) at high doses, making it a useful model compound for SARM partial agonism and tissue selectivity research. Research use only.
Research Applications
Partial AR Agonism Research
Partial vs full agonist efficacy comparison — Emax, tissue selectivity, coactivator recruitment
Muscle & Bone Anabolism
Anabolic activity at partial agonist efficacy — lean mass, bone density models
Retinal AR Research
S4-mediated visual disturbances — retina AR expression, off-target tissue binding
Prostate SARM Pharmacology
Partial agonist in prostate tissue — BPH model comparison with full agonists
Comparative SARM Studies
S4 partial agonism vs Ostarine, LGD-4033, RAD-140 full agonist — receptor pharmacology
Quick Specs
| Form | C₁₉H₁₈F₃N₃O₆ |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 401900-40-1 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months unopened |
| Storage | Room temperature sealed | cool, dry storage |
| Manufacture | In-house synthesis — Qingdao, China |
| Brand | China |