What is Isotretinoin?
Isotretinoin (13-cis-retinoic acid) is a synthetic retinoid — the most potent oral sebosuppressive agent known. Binds RARα/β/γ and RXR nuclear receptors, reducing sebaceous gland size and activity, inducing apoptosis in sebocytes, and normalising keratinocyte differentiation. Additionally studied for anti-inflammatory, anti-proliferative (neuroblastoma), and differentiating effects. Research use only.
Research Applications
Sebaceous Gland Biology
Sebocyte apoptosis, sebum production suppression, SCD1/FASN pathway
RAR/RXR Receptor Pharmacology
Retinoid receptor binding, retinoic acid response element (RARE) activation
Keratinocyte Differentiation
Follicular hyperkeratinisation inhibition, comedogenesis models, skin barrier
Neuroblastoma Differentiation
Neural crest cell differentiation, MYCN suppression, neurite outgrowth
Anti-Inflammatory Skin Research
Innate immune pathway modulation in sebaceous gland inflammation, TLR2 signalling
Quick Specs
| Form |
C₂₀H₂₈O₂ |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
4759-48-2 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
Room temperature sealed | protect from light | cool, dry storage |
| Manufacture |
In-house synthesis — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
QSC research tablets are supplied as pre-dosed oral tablets at the stated concentration. No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications.
How should this peptide be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight. Keep in the original container. Properly stored tablets remain stable for 2–3 years.
What purity is this QSC compound and how is it verified?
QSC research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
Room temperature sealed | protect from light | cool, dry storage
