What is Dihexa?
Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an angiotensin IV analogue that potently activates the HGF/c-Met receptor signalling pathway — reported to be ~10⁷× more potent than BDNF in synaptogenesis assays. HGF/c-Met activation promotes dendritic spine formation, hippocampal synaptic density, and neuronal repair. Studied as a cognitive enhancer, synaptogenic agent, and neurodegeneration research tool. Research use only.
Research Applications
HGF/c-Met Receptor Signalling
c-Met activation, downstream ERK/PI3K/Akt cascades, receptor specificity
Synaptogenesis Research
Dendritic spine density, synapse formation, pre/postsynaptic marker expression
Cognitive Enhancement Models
Morris water maze, novel object recognition, Barnes maze — hippocampal-dependent learning
Neurodegeneration Research
Alzheimer’s, Parkinson’s, TBI models — synaptic density preservation
BDNF Pathway Comparison
Dihexa vs BDNF, NGF — synaptogenesis potency, receptor pathway overlap
Quick Specs
| Form |
C₁₅H₂₃N₃O₄ (angiotensin IV analogue) |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
1172133-28-6 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months unopened |
| Storage |
Room temperature sealed | cool, dry storage | protect from light |
| Manufacture |
In-house synthesis — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
QSC research tablets are supplied as pre-dosed oral tablets at the stated concentration. No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications.
How should this peptide be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight. Keep in the original container. Properly stored tablets remain stable for 2–3 years.
What purity is this QSC compound and how is it verified?
QSC research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
Room temperature sealed | cool, dry storage | protect from light
