What is Dapoxetine?
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) with rapid absorption and fast elimination — pharmacokinetically distinct from chronic SSRIs. Inhibits the serotonin transporter (SERT), acutely elevating synaptic 5-HT. Designed for on-demand use due to its rapid Tmax (~1.3h) and short half-life (~1.5h). Research tool for SERT pharmacology, acute serotonergic signalling, ejaculatory reflex modulation, and short-acting SSRI pharmacokinetics. Research use only.
Research Applications
SERT Pharmacology
Serotonin transporter inhibition, synaptic 5-HT elevation, acute vs chronic SSRI kinetics
Acute Serotonergic Signalling
Short-duration 5-HT increase — receptor occupancy, desensitisation timeline
Ejaculatory Reflex Research
Central 5-HT modulation of ejaculatory latency, spinal ejaculation generator
Short-Acting SSRI PK Studies
Rapid Tmax, short T½, metabolite (desmethyldapoxetine) kinetics vs chronic SSRIs
Sexual Function Neuroscience
Serotonergic control of sexual response, dopamine interaction, limbic circuitry
Quick Specs
| Form | C₂₁H₂₃NO₂ |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 119356-77-3 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months unopened |
| Storage | Room temperature sealed | cool, dry storage |
| Manufacture | In-house synthesis — Qingdao, China |
| Brand | China |