What is P21-adamantane?
P21-adamantane is a modified neurotrophin-mimetic peptide derived from the CNTF (ciliary neurotrophic factor) sequence, with an adamantane moiety attached to enhance blood-brain barrier penetration and receptor engagement. Activates STAT3/JAK signalling and BDNF expression. Studied for hippocampal neurogenesis, cognitive enhancement, and neuroprotection models, with the adamantane modification providing superior CNS bioavailability compared to unmodified P21. Research use only.
Research Applications
Hippocampal Neurogenesis
Dentate gyrus progenitor cell proliferation, BrdU/EdU incorporation, DCX expression
BDNF Upregulation
BDNF mRNA and protein expression, TrkB signalling, CREB phosphorylation
STAT3/JAK Pathway Research
CNTF receptor complex activation, STAT3 nuclear translocation, target gene profiles
Blood-Brain Barrier Penetration
Adamantane moiety CNS uptake vs unmodified peptide — pharmacokinetic comparison
Cognitive & Memory Research
Morris water maze, novel object recognition, LTP modulation in rodent models
Quick Specs
| Form |
Adamantane-AEAEAAAKEAAAKAAE (modified CNTF loop), |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
2411025-13-3 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months (unopened) |
| Storage |
-20°C sealed | 2–8°C reconstituted (3 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1 mL bacteriostatic water to the lyophilized vial, directing liquid down the inner wall. Swirl gently until clear — takes 2–3 minutes due to the hydrophobic adamantane modification. Slight warming to 37°C can aid dissolution if needed.
How should this peptide be stored?
Store lyophilized vials at −20°C. Reconstituted solution is stable at 2–8°C for up to 3 weeks. The adamantane moiety is susceptible to aggregation at high concentrations — avoid freeze-thaw cycling.
What purity is this QSC compound and how is it verified?
Adamantane is a lipophilic cage molecule that dramatically improves CNS penetration by facilitating passage through the blood-brain barrier. P21-adamantane shows superior hippocampal BDNF upregulation and neurogenesis compared to the unmodified P21 peptide in published research models.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (3 weeks)
