What is B7-33?
B7-33 is a single-chain peptide analogue of the relaxin-2 B-chain, engineered to selectively activate RXFP1 (relaxin family peptide receptor 1) while avoiding the native two-chain structure of relaxin-2. Studied for anti-fibrotic effects, collagen remodelling, vasodilation, and cardioprotection — without the insulin-like A-chain that complicates full relaxin manufacture. Represents a simplified, single-chain RXFP1 agonist for fibrosis and cardiovascular research. Research use only.
Research Applications
Anti-Fibrotic Research
Collagen I/III expression suppression, MMP upregulation, TGF-β pathway modulation
RXFP1 Receptor Pharmacology
Receptor binding kinetics, cAMP/PKA signalling, β-arrestin recruitment
Cardiac Fibrosis Models
Post-infarct remodelling, myocardial stiffness, cardiac fibroblast activity
Vasodilation & Vascular Biology
NO-mediated vasodilation, endothelial function, arterial compliance
Single-Chain Relaxin Analogue Studies
B7-33 vs full relaxin-2 pharmacodynamic comparison, potency, selectivity
Quick Specs
| Form |
Single-chain relaxin B-chain analogue, ~3,800 Da |
| Purity |
≥99% by HPLC — every batch |
| CAS Number |
2413928-17-1 |
| Molecular Weight |
MS molecular weight confirmed — every batch |
| Specification |
≥99% by HPLC — every batch |
| Shelf Life |
24 months (unopened) |
| Storage |
-20°C sealed | 2–8°C reconstituted (4 weeks) |
| Manufacture |
In-house Fmoc SPPS — Qingdao, China |
| Brand |
China |
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1 mL bacteriostatic water to the lyophilized vial, directing liquid down the inner wall. Swirl gently until clear — dissolves within 1–2 minutes. The 6mg vial provides a concentrated stock suitable for dilution to working concentrations.
How should this peptide be stored?
Store lyophilized vials at −20°C. Reconstituted solution is stable at 2–8°C for up to 4 weeks. Avoid repeated freeze-thaw cycles. B7-33 is relatively stable due to its engineered single-chain structure.
What purity is this QSC compound and how is it verified?
Native human relaxin-2 is a two-chain peptide (A and B chains linked by disulfide bonds) requiring complex manufacture. B7-33 achieves selective RXFP1 agonism from a single synthesisable chain, enabling more reproducible research with comparable pharmacological activity at the receptor level.
🧪 Peptide Research Tools: Use QSC's free
peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION
QSC products are strictly for in vitro and in vivo laboratory research.
Safety & Handling
🚫
Not for Human Use
These compounds are for research only.
🥽
PPE Required
Always use appropriate protective equipment.
❄️
Storage Compliance
Follow product-specific storage conditions.
Product-Specific Storage
-20°C sealed | 2–8°C reconstituted (4 weeks)
