What is Triptorelin?
Triptorelin is a synthetic decapeptide agonist of gonadotropin-releasing hormone (GnRH), with D-Trp substitution at position 6 conferring greater GnRH receptor affinity and proteolytic resistance compared to native GnRH. Continuous or high-frequency exposure produces receptor downregulation and pituitary desensitisation, suppressing LH/FSH secretion and downstream gonadal steroidogenesis. Used as a pharmacological HPG axis suppression tool and GnRH receptor pharmacology reference compound. Research use only.
Research Applications
HPG Axis Suppression
LH/FSH downregulation, pituitary desensitisation, gonadotropin washout kinetics
GnRH Receptor Pharmacology
Receptor binding affinity vs native GnRH, internalisation, downregulation dynamics
Testosterone/Estrogen Suppression
Castrate-level androgen/estrogen research models — hormone-sensitive tissue studies
Pituitary Sensitivity Reset
Post-anabolic/post-HRT HPG axis reactivation studies using single-dose protocols
Prostate & Hormone-Sensitive Cancer Models
Androgen deprivation, castration-resistant transition, tumour growth modelling
Quick Specs
| Form | C₆₄H₈₂N₁₈O₁₃, MW 1311.5 |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 57773-63-4 |
| Molecular Weight | MS molecular weight confirmed — every batch |
| Specification | ≥99% by HPLC — every batch |
| Shelf Life | 24 months (unopened) |
| Storage | -20°C sealed | 2–8°C reconstituted (4 weeks) |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Brand | China |